AbstractLettuce and cucumber are two essential salad ingredients that must be included for the dish to be complete. In the current study, we carried out a small pilot study on the co-cultivation of lettuce and cucumber in an effective aquaponics system. The experiment lasts for a total of four months, during which time the lettuce and cucumbers are grown for three and four months, respectively. In between the lettuce plants, which were grown at a density of 17 plants per square meter, the cucumber plants were planted at a density of 3 plants per square meter. Each month, the physicochemical quality and yield performance of harvested lettuce and cucumbers were evaluated. In the mixed cultivation method, lettuce and cucumber produce more, and the biochemical reports reveal no significant change over the course of the entire experimental period. The third month of lettuce production revealed a significantly lower overall yield. The final results showed that both crops were successfully utilizing the nutrients in the aquaponics water, demonstrating the efficiency of the nitrification process in the aquaponics environment. According to the findings, the current experiment suggests cucumber and lettuce be grown together, which is suitable for aquaponics systems. The study also found that cucumber and lettuce can be grown together in an aquaponic system without any negative effects on either crop.